The purpose of this work is to analyse the well-posedness and the blow-up of solutions of the higher-order parabolic semilinear equation
ut+(-Δ)du=|x|α|u|p+ζ(t)w(x) for (x,t) ∈ ℝN×(0,∞),
where d ∈ (0,1) ∪ ℕ, p > 1, -α ∈ (0, min(2d,N)) or α ≥ 0 and ζ as well as w are suitable given functions. The novelty here regards to previous works lies in considering a forcing term ζ(t)w(x) depending on both time and space variables, a fractional or high-order Laplace operator (-Δ)d, and a weighted (possibly singular) non-linearity |x|α|u|p. We prove small Lebesgue data global existence for p larger than a critical value depending on the behavior of ζ. Furthermore, the global existence fails to hold for p less than the critical value under the additional condition ∫ℝN w(x) dx > 0. As a consequence, we derive the explicit value of the Fujita exponent pF(σ) in the case ζ(t)=tσ, σ > -1.

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